In 1973, Mindy Sterling landed a recurring role on the syndicated children’s series Dusty’s Treehouse. She later joined the L.A.-based comedy troupe The Groundlings. Despite having starred in numerous films in the 1980s and 1990s, it was her character Frau Farbissina, the diminutive and domineering Germanic cohort of Dr. Evil (Mike Myers) in Austin Powers: International Man of Mystery, which brought Sterling high praise for her work in films, being a marvelous takeoff of Lotte Lenya who played Rosa Klebb in From Russia with Love in 1963.
From 1990 to 1991, she was one of the comedians in the satirical show On the Television. Sterling played Christian Slater’s secretary Arlene Scott in the show My Own Worst Enemy. She also played Judge Foodie on the Disney show That’s So Raven and a volleyball coach on The Suite Life of Zack & Cody. She appeared as the wedding planner on the Friends episode “The One with Barry and Mindy’s Wedding” in 1996, and in 2004, as the casting director on the episode “Joey and the Big Audition” of Joey. In 1999, following the success of Austin Powers: The Spy Who Shagged Me, Sterling appeared in Drop Dead Gorgeous (also 1999), and later reprised the character Frau Farbissina in Austin Powers in Goldmember for the third and final time.
In 2000, Sterling appeared as a celebrity guest on Hollywood Squares. She returned to the show in 2002. She played one of the townspeople in the live-action adaptation of How the Grinch Stole Christmas, and also provided additional voices in the 2018 CGI version, The Grinch. Between 2002 and 2004, Sterling made guest appearances on the Donny Osmondv ersion of the game show Pyramid.
From 2007 to 2010, Sterling voiced Ms. Endive, the main antagonist to Mung Daal in Chowder. She voiced the character Lin Beifong, the second Police Chief of Republic City and daughter of original chief Toph Beifong, in The Legend of Korra. She also had a recurring voice role as Morgana on the Nickelodeon version of Winx Club in 2012. Her many other voice-over credits include guest roles on The Wild Thornberrys, Invader Zim, Ice Age: The Meltdown, American Dragon: Jake Long, Higglytown Heroes, Robot Chicken, Mars Needs Moms, The Looney Tunes Show, Justice League Unlimited, Kick Buttowski: Suburban Daredevil and Scooby-Doo! Mystery Incorporated.
Sterling has achieved success in teen sitcoms, playing Ms. Francine Briggs on iCarly, and in A.N.T. Farm as Principal Susan Skidmore. In 2010, she had a recurring role as bitter neighbour Mitzi Kinsky in Desperate Housewives. In 2012, she appeared in a book trailer for a parody of The Hunger Games entitled The Hunger Pains. In 2013, she starred as Janice Nugent in the comedy series Legit. In 2018, she appeared in Netflix’s A Series of Unfortunate Events. From 2017 to 2023, she appeared on the sitcom The Goldbergs as Linda Schwartz, the mother of Geoff Schwartz.