At the age of two, Jordan Ladd began appearing in commercials. Her first commercial was for Polaroid. She began acting in film and television while in school, working with her mother Cheryl Ladd in made-for-television films such as The Girl Who Came Between Them (1990) and Broken Promises: Taking Emily Back (1993). After graduating high school, she took up acting professionally.
In 1994, she guest-starred in an episode of the NBC series Saved by the Bell: The New Class and made her big screen debut with a supporting appearance as a promiscuous college student opposite Alyssa Milano in the film Embrace of the Vampire. She spent the majority of the 1990s appearing in a variety of independent films in 1997, including Inside Out, Nowhere, and Stand-ins. In 1999, she appeared in Taking the Plunge, and also landed her first high-profile role alongside Drew Barrymore as a popular student who tortures an insecure copy editor in the teen comedy Never Been Kissed. The film was a commercial success, grossing US$84.5 million globally, and gave her an initial wide exposure with audiences.
Ladd appeared in The Specials (2000), a comedy about a group of superheroes on their day off; in the film she played a neurotic named Nightbird. By 2000, she also had starred as an actress who vying for an Academy Award in E! first original film Best Actress, and appeared in the critically acclaimed anthology film Boys Life 3.
Ladd starred as a college graduate and the victim to a flesh-eating virus in the horror film Cabin Fever (2002), Eli Roth’s directorial debut. It was with this film that she began work in the horror genre, as she had a “real education on that way of storytelling” with Roth and the film.That same year, she played a crying woman in David Lynch’s Japanese-style horror short Darkened Room.
In 2004, Ladd took on the role of a suspect in a recent string of murders on a vacationing island in the horror comedy Club Dread, and starred as a mental health facility nurse in the horror Madhouse. In 2005, she appeared opposite Anna Faris, Ryan Reynolds and Justin Long in the independent romantic comedy Waiting…, and in 2006, she briefly appeared in David Lynch’s film Inland Empire, which also starred her mother.
Quentin Tarantino cast her as a wild, partying Texan and the victim of a killer stuntman in Death Proof, his high-speed segment of the double–feature exploitation horror Grindhouse (2007), alongside Rosario Dawson, Tracie Thoms, Zoë Bell, and Kurt Russell. Director Eli Roth, in his contribution to Grindhouse, worked again with Ladd in a fake promo called Thanksgiving, which she shot “on the fly over” in Prague, where Hostel: Part II was being filmed; in the horror sequel, she played the girlfriend of the sole survivor of the first film.
In her next film, the horror Grace (2009), Ladd portrayed a woman, who after a car accident, decides to carry her unborn baby to term anyway. In 2009, she also starred in the made-for-television film The Wishing Well, as a journalist from New York City who gets sent to a small town in Illinois to report on a legendary wishing well.
Ladd filmed a comedic short film entitled First Dates, exploring the dating scene of several single people. The production premiered at the AFI screening room in Los Angeles on January 8, 2011. She starred in the fantasy romance film Awaken(2012), which premiered at the Newport Beach Film Festival, as a mysterious woman who changes the mundane life of a man. In 2012, she also appeared in the direct-to-DVD disaster film Air Collision, as a flight attendant, and in the thriller Murder on the 13th Floor, as a wife who discovers her husband is having an affair with the live-in nanny and decides to seek revenge.
In 2015, Ladd guest-starred in an episode of the YouTube horror anthology series Scary Endings, directed by John Fitzpatrick. In 2016, she reunited with Fitzpatrick for the short thriller film Brentwood Strangler, in which she played a lonely woman goes on a blind date with a man who, unbeknownst to her, was replaced by an active and notorious serial killer, opposite Adam J. Yeend and Annika Marks.
In 2017, Ladd starred in the made-for-television thriller Stage Fright, as an opera soprano facing a series of dangers, and in the independent drama Blue Line, as a woman who, along with her best friend, go on a crime spree to rob her abusive husband and escape her marriage.