Wuhl’s first role in movies was a starring role in the 1980 comedy The Hollywood Knightsalong with other fledgling actors Tony Danza, Michelle Pfeiffer, and Fran Drescher, followed by a small role in the film Flashdance (1983). Wuhl had larger roles in films including Good Morning, Vietnam (1987) with Robin Williams, Bull Durham (1988) with Kevin Costner, Tim Burton’s 1989 Batman (as reporter Alexander Knox) with Michael Keaton, Blaze (1989) with Paul Newman, Missing Pieces (1991) with Eric Idle,
Mistress (1992) with Robert De Niro, Blue Chips (1994) with Nick Nolte, and Cobb (1994) with Tommy Lee Jones. He wrote two of the six episodes for the TV series Police Squad! in 1982 and did an audio commentary for its release on DVD in 2006.
He and Keith Carradine appeared in the 1985 music video to Madonna’s “Material Girl”. In 1992, he appeared in The Bodyguard as host of the Oscars.
Wuhl won two Emmy Awards for co-writing the Academy Awards in 1990 and 1991 with Billy Crystal, Bruce Vilanch, David Steinberg, and others.
From 1996 to 2002 he wrote and starred in the HBO series Arliss as the title character, an agent for high-profile athletes.
From 2000 to 2001, he was a frequent panelist on the ESPN game show 2 Minute Drill, often quizzing the contestants on sports-related movies.
In 2006, he starred on HBO in a one-man-show, Assume the Position with Mr. Wuhl, where he taught a history class to show how history is created and propagated in a similar fashion to pop culture. A second chapter entitled Assume the Position 201 with Mr. Wuhlaired on HBO in July 2007.
Wuhl hosted a sports, sports business and entertainment daily talk radio show, for Westwood One (now Dial Global) from January through December 2011. Wuhl occasionally fills in for Boomer Esiason on the Boomer and Carton show.
Wuhl played “Herb Tucker” in a revival of Neil Simon’s play I Ought to Be in Pictures. In 2017, he appeared with Don Most in another Simon play, The Sunshine Boys, at Judson Theatre Company.
Wuhl has appeared as himself in four episodes of American Dad!: the 2015 episode “Manhattan Magical Murder Mystery Tour”, the 2017 episode “The Talented Mr. Dingleberry”, the 2019 episode “One-Woman Swole”, and the 2021 episode “Cry Baby”.