Lorraine Bracco moved to France in 1974, where she became a fashion model for Jean-Paul Gaultier. She lived there for about a decade. While still modeling, Bracco was approached by Marc Camoletti, who offered her a major role in the film adaptation of one of his plays, Duos sur canapé (1979). Bracco did not imagine that she could be an actress, and initially refused. She eventually made the film, but found the experience “boring” and her performance “terrible.” Nevertheless, she played supporting roles in two other French films “for the money.”
After one of her friends suggested that she might enjoy acting if she took some training, she took seminars with John Strasberg. Although she loved the lessons, she was still unsure of her talents.
During the 1980s, she worked as a disc jockey for Radio Luxembourg. She also appeared as Paul Guilfoyle’s hostage in the first season of the series Crime Story, in the episode “Hide and Go Thief”. Her sister Elizabeth played a coffee shop waitress in the series pilot.
Eventually, Italian director and novelist Lina Wertmüller gave Bracco a small part in the film Camorra. The experience inspired Bracco to pursue acting.
Bracco received her big career break when she was offered the role of mobster wife Karen Hill in the Martin Scorsese directed crime drama Goodfellas (1990). Her performance earned her an Academy Award nomination for Best Supporting Actress and a Golden Globe nomination for Best Supporting Actress – Motion Picture. She won the Los Angeles Film Critics Association Award for Best Supporting Actress and the Chicago Film Critics Association Award for Best Supporting Actress.
Her other films include Someone to Watch Over Me (1987), Switch (1991), Medicine Man (1992), Radio Flyer (1992), Hackers (1995), The Basketball Diaries (1995), and Riding in Cars with Boys (2001).
During the audition process for The Sopranos, David Chase wanted Bracco to audition for the lead female role of Carmela Soprano. However, Bracco had read the script and was drawn to the part of psychiatrist Jennifer Melfi as she wanted to try something different and felt that the part of the highly educated Dr. Melfi would be more of a challenge for her. Bracco felt so strongly about her ability and desire to play the part that she arranged a meeting with Chase and talked him into letting her have a chance as Melfi. The role netted her three consecutive nominations for Outstanding Lead Actress in a Drama Series at the Emmy Awards in 1999, 2000, and 2001, and at the Golden Globe awards for Best TV Actress in a Drama in 2000, 2001, and 2002. She was nominated again at the 2007 Emmy Awards for Outstanding Supporting Actress in a Drama Series.
Bracco is the owner of Bracco Wines, in association with Straight-Up Brands LLC. Her line of wines was featured on the Season 1 finale of Bravo’s show Top Chef in 2006. She appeared as a guest judge for the show’s two-episode finale and as a special judge on Top Chef: All-Stars, in the episode titled “An Offer They Can’t Refuse”, which featured Italian cuisine. Bracco also appeared on a season 6 episode of Throwdown! with Bobby Flay, as a guest judge for the ravioli throwdown.
From 2010 to 2016, Bracco co-starred on the TNT crime drama Rizzoli & Isles as Angela Rizzoli, mother of Jane Rizzoli, portrayed by Angie Harmon. She appeared in all 105 episodes of the series over its seven-season run.
Beginning in 2016, Bracco had a recurring role as Toni on the Showtime comedy series Dice. In 2017–2018, she had a five-episode recurring role as Mayor Margaret Dutton in the CBS police drama series Blue Bloods.
Also in 2020, Bracco starred in the HGTV documentary television series My Big Italian Adventure. Shot in Sambuca di Sicilia, it chronicled her renovation of a 200-year-old house she purchased for €1 at Via Guglielmo Marconi.
In 2022, Bracco worked in the Robert Zemeckis remake of Pinocchio where she voiced Sofia the Seagull.
In 2023, Bracco starred in Waheed AlQawasmi’s debut film Jacir as Meryl, an opioid addicted next-door neighbor of a Syrian refugee living in poverty in Memphis, Tennessee, delivering an emotionally charged performance that was dubbed “her best performance since Goodfellas.”